This study is designed for adults with Moderate to sever AD whose disease cannot be adequately controlled with topical medications of for whom topical treatment is inadvisable (intolerance, etc) Requires subjects have had chronic AD for at least three (3) years, effecting at least 10% of body surface. Must have documented inadequate response to a prior therapy (can mean failure to achieve and maintain a low disease state despite treatment with a daily regimen of TCS). If a subject required systemic treatment in the last six (6) months, that is also considered in adequate response. Study agent is dupilumab, a fully-human monoclonal antibody. Fewer side effects than most other monoclonal drugs (primary complaint = cold like symptoms). Responders to medication may continue into one or two extension studies, meaning total treatment time could be two years +/-. A Phase 3 Placebo controlled Study Investigating the Efficacy and Safety of Multiple Dupilumab Dose. Regimens Administered as Monotherapy for maintaining Treatment Response in Patients with AD. Most study participants receive stipend for each visit completed, in addition to safety assessments (labs, EKGs, Physician exams, etc)

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